Isabella Strahan is mourning the loss of a close friend whose life was shaped by the same illness she once fought herself.
On Sunday, the daughter of former New York Giants defensive end Michael Strahan used her Instagram Stories to pay tribute to Seana Isaac, who died of cancer on January 25, 2025. The posts included a childhood photo originally shared by Seana’s mother, Shasha Isaac, along with a message announcing her daughter’s passing.
Another image featured a letter Seana wrote before her death. In the note, she thanked those who supported her over the last two and a half years and reflected on what her illness had taught her about faith and love.
“Yes, I am suffering, but I am uniting that suffering with God,” Seana wrote. “We can all unite our sufferings with the Lord. I can say I’ve lived a full life here on earth, but this life is temporary. Our life is about eternity. John 3:16 ‘…whoever believes in him shall not perish but have eternal life.’ That is the legacy I want to leave behind. Love, Seana.”
Isabella also reshared a February 2025 post from Seana that included a photo of the two standing with their arms around one another. In that earlier caption, Seana described meeting Isabella as an “instant wave of happiness” and expressed gratitude for participating in Isabella’s documentary aimed at raising awareness for pediatric cancer.
Isabella’s twin sister, Sophia, also commented under the post and wrote, “rest in peace Seana🩷🩷 sending my love.”
“My biggest inspiration in every lifetime,” Isabella wrote in her tribute. “She truly was exceptional.”
The public remembrance comes after Isabella’s own battle with medulloblastoma, a rare and aggressive brain cancer that forms in the cerebellum. She was diagnosed in October 2023 at age 20 and underwent multiple brain surgeries along with four rounds of chemotherapy.
In July 2024, doctors declared her cancer-free.
She later documented her experience on YouTube in a video titled Goodbye Hospital, revealing that her final scans were clear. The following month, she returned to the University of Southern California.
In 2025, Isabella partnered with ABC Network for a documentary titled Life Interrupted: Isabella Strahan’s Fight to Beat Cancer. In the film, doctors discussed the early risks she faced, including seizures, stroke, and death, while Isabella addressed misconceptions about treatment and recurrence.
Her story — and her tribute — reflect a shared journey marked by resilience, faith, and remembrance.
